Responses about Zometa

Lyuba:

Concerning injection of Zometa I talked with oncologists from Leningrad oncological dispensary and with our oncologists. To me have told that enter it usually together with chemotherapy: if chemotherapy do every 3 weeks, then do Zometa also every 3 weeks, if chemotherapy do every 4 weeks, then do Zometa - every 4 weeks too.

If you do not have chemotherapy, then, it seems to me, it is better Zometa to do every 4 weeks, as:

- The oncologist from Leningrad said to me that Zometa operates 4 weeks, and the instruction confirms it

- In order to avoid serious by-effects of Zometa it is undesirable to give an injection more than two years (if to give an injection once a month).

Sometimes Zometa (or others bisphosphonates) do more than 2 years. But, probably, it is necessary to approach to each patient individually. However the doctor from the Leningrad oncological clinic said to me that they prefer not to enter Zometa more than 2 years. And such instructions have arrived in our oncological clinic since 2008 when, to enter Zometa, have started to demand the analysis of blood with a calcium indicator, and at low calcium, Zometa do not enter.

… Zometa already use long time as a preparation for osteoporosis treatment. I have met a considerable quantity of the legal firms preparing claims to manufacturers of Zometa, and collecting the information about suffered from Zometa. As the mechanism of action of Zometa up to the end is not studied, experts cannot understand the reason of this complication. At some patients the osteoporosis of the bottom jaw, with the loss of teeth and full necrosis of the bottom jaw began. This complication arose at some patients in the course of treatment by Zometa, and at some after some years after the treatment termination.

… the given complication can be caused not necessarily only by Zometa, but also any bisphosphonate.

This information at first has made upon me depressing impression, but having compared advantage which can bring Zometa and, without forgetting about maintenance of level of calcium, I’ve used it. However, preliminary, for calm, we have made an X-ray a jaw picture in stomatologic clinic (for check on an osteoporosis).

Mihailka:

And to us chemotherapeutist has told that Zometa it is desirable to enter one time in 4 weeks, and mammologist said - once in 3 weeks.

Actually, complications not can to be. How much I have understood, this question is not up to the end studied.

Nevertheless, the oncologist said to me that if calcium level to hold in norm, complications will not be.

Yulyasha:

To me they drop Zometa one time in 28 days more than two years.

Mura:

Long application of high doses of bisphosphonates on oncological patients can bring in rare instances to osteonecrosis of a jaw, but practically these patients in all cases, or have passed any surgery (removal of teeth) or used dentures. Only in very small amount of cases osteonecrosis developed at the people accepting standard doses of bisphosphonate for treatment of an osteoporosis.

To the patients, who take intravenous injections of bisphosphonate, recommend to observe hygiene of a mouth and not to undertake any surgical interventions in an oral cavity during taking bisphosphonates.

Ejachok:

… have entered Zometa for the first time. As out-patient.

Blood indicators: urea, Creatinine, ionogram, bilirubin directly before application of Zomety was in norm.

Next days, very strongly twisted knees, was ill in a groin and perineum and there was the feverish condition similar on influenzal. Any medicines did not take.

In some days: still there were pains in knees. Pains in a groin and perineum have passed. The temperature has risen to 39. Temperature is reduced with medicines (suppository).

Next day: high temperature and influenzal condition are not present, but there are severe pains in feet (from knees and above to a pelvis). To sleep is not probably. It is necessary to take analgetics.

PS.: Doctor did not recommend the first 2 weeks after Zometa to take Calcium-D3 and to do not take in food any milk products.

Irina:

At me the temperature after the first taking of Zometa raised, the high temperature kept twenty-four hours, at the subsequent takings – no any appreciable changes of state of health. From the unpleasant: I can not stretch myself, I got a cramp in my legs.

As I have understood, Zometa accumulates in a bone tissue and does not allow to "wash away" from it own calcium, and also, «when an opportunity presents it grasps external calcium", but if to enter calcium (preparations or products), Zometa which yet have "not settled" in bones, will tie up "free calcium" and will leave an organism without advantage.

I has endured Rezorba subjectively worse - the temperature 37.5 kept some days, the influenzal phenomena (nasal catarrh, an ache), I got a cramp in my legs more strongly and more often, even in the sleep. About efficiency of Rezorba - I can not tell anything.

Zometa will not solve the Compression of a vertebral column, and it is not an antineoplastic preparation. In most cases Zometa - a palliative against a pain and preventive maintenance of fracture at bone metastasis.

Magen:

They warn us in a clinic after enter of Zometa, that 3 days do not eat any milk products and in a current of week did not visit the stomatologist. I took Zometa about one year, it is frequent after taking, and sometimes even in a week, there is "an influenzal" condition – high temperature, a fever, and a pain in all body. Sometimes even there is a cough-cold! Firstly each time I thought that it is flu, and now I understand that no cough for 2 days disappears, and every time for the third day I am already absolutely healthy and happy! Good luck, be not ill, and be not depressed also all will pass. By the way, me too it is entered by each 28 days.

Evgen:

Hello. My mother-in-law is 57 years old. She has a backbone osteoporosis. She has pains under a breast and shoulder-blades as have drawn with rope.

She has injection Zometa as out-patient. A condition is as to injection.

Next day: she has “weight” in feet, a feverish condition; temperature has risen to 38-39 Degrees. They reduced high temperature with "Paracetamol".

After another day: no high temperatures, no feverish condition. Became heavier to walk, her legs gave way; “weight” in feet.

After another day: she has pains in feet, under a breast and shoulder-blade. She lies, does not rise, cannot walk; badly sleeps.

After another day: She has started to take "Tramadol" - pains became less, but a condition is same.

IS A GLASS OF WINE A DAY GOOD FOR YOU

My girlfriend drinks 1-2 glasses of red wine in day at meal, instead of tea. Tell me such volume it is alcoholism or not? How many in general it is possible to drink weak alcohol in a day not including it alcoholism, even in insignificant degree. The girlfriend speaks that in France they drink a wine bottle in a day, instead of drinks is considered it during meal, at them it is the norm. It is truth?

Raduga: Well not a bottle and a wine glass by a dinner ~ 100ml. About advantage: certainly, red dry wine - one of the strongest antioxidants. But I think that hardly it is useful to drink A GLASS OF WINE every day. An important question - wine we drink is natural, is useful? … A standard glass for wine it is about 200 ml, but pour wine on half, it is no more.… Ethyl spirit is certainly poison, a matter in quantity. So it is possible to decompose a water to components and to tell, for example, that it is poisonous because of the chlorine maintenance… In general, I do not advance idea of advantage of wine specially. I am fond dry red wine only and for me personally, as well as to the Omar Khayyam; it improves mood and general state.

Karen: About one year back I watched interesting telecast about advantage of a glass of wine. It has appeared, it is disputable enough true. Medicine and manufacturers of wine are in collusion: advertise such “prophylactic”. …. the true in dispute was not born, though shout was enough. And I have not understood, whether there is an advantage of such cultural use of a glass of wine or harm. …. About advantage of a glass of red wine: I think it is no more, than a myth. Eat incorrectly, lie on a sofa - hardly the glass of red wine will prolong your life ….

Jemma: It seems to me that there actually at Frenchmen with wine, anybody precisely does not know. Well and their wine is precisely another. I do not trust more in utility of any alcoholic drinks, even in small amounts - I perceive these "doctrines about advantage of alcohol" as business.

Anatoliy: … Yes, A GLASS OF WINE A DAY GOOD FOR YOU. And the dose depends on a food. Ancestors of Frenchmen drank glasses of wine in hundreds years. At them it was generated feature to neutralization of alcoholic poison. And, if the representative of the nationality which ancestors did not drink wine, tries such to repeat - he turn in a month to the alchy. … The dose of the SOBER person is equal to ZERO))... So do not justify. … DRINK NATURAL JUICE is better and there will be to you a health)) You in general know that means a word an antioxidant. Manufacturers of wine have hung up tempting labels, and people thoughtlessly repeat: "O-o-o, it is an antioxidant. It is necessary to drink for appetite..."

Oinka: Frenchmen drink the diluted wine. So concentration of alcohol in it is less, than in that wine which is usually drunk. And in general, the degree of alcoholic intoxication (easy, average, strong intoxication, a poisoning) is defined on a scale calculated on average drinking European. So, all is relatively. Someone gets drunk with a glass of wine, and for someone two bottles of vodka has not enough!

Dimon: …There is one more minus. It is noticed by the same Frenchmen. In the north of France where drink only imported wine, they are ill much more often, than in the south of France, where is drunk natural wine. Further. Young wine, that we see that give to children, it practically is juice. It is really diluted with water and drunk as a soft drinks. Alcohol there is from 1-7%. But not 9-12 %. Wine is useful. And really good wines cost much. And in general, juice and wine - basically the same. As soon as fermentation process started – it is young wine. Grain natural kvass has the same percent of alcohol. No harm from it - it is obvious. And it not makes you alchy.

Fiume: I do not know how is in France, I was not there, but I can tell about Croatia, in which there I live 4 years. When you come on a visit, they ask "white (wine) or red (wine)"? They do not offer tea, coffee. They drink wine, but do not revel. To Croatia the grapevine was delivered in the ancient time by Greeks and since then in this land - a glass of wine is integral part of life. At people it already in a gene code. They drink dry Wine only, diluted or in the pure state. In Kiev I did not drink some wines - the allergic rhinitis at once began. In Croatia I drink a glass of wine without consequences. The wine from south regions is easier drunk and it is easier to be endured, and sometimes the organism asks it. In sanatoria of Crimea for a dinner always a glass of red dry wine gave, I think, and now give. It is better to regularly drink a glass of wine, than to revel on holidays. ….

Niusya: I consider that wine should be bought there, where it make. Natural red dry wine IS a magnificent antioxidant. In Brazil even cosmetics manufactures by the name of different brands of grapes. They use all useful behaviors of grapes. I never abuse winemaking.

Tolia: This point in question can be considered from the several points of view. For example, if to speak about qualitative and rather weak (dry) wine as an antioxidant, drinking at dinner a glass of wine it is undoubtedly useful. But! On the other hand, any alcohol how qualitative would not be, kills cells (neurons) of brain. Therefore any alcohol is unhealthy. The wine is not harmful only in absolutely small amounts…

Polet: I think that one-two glasses of red wine in a day in any way it is impossible to consider the use of as alcoholism. The moderate use of wine has a number of positive factors - digestion improvement, blood pressure normalization etc.